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Thursday, July 19, 2012

Widely prescribed MS treatment may not slow progression of disease

Wednesday, July 18, 2012

Researchers with the UBC Hospital MS Clinic and Brain Research Centre at Vancouver Coastal Health and the University of British Columbia have published important data in the Journal of the American Medical Association (JAMA) about the impact of a common drug therapy on the progression of multiple sclerosis for people with the relapsing?remitting form of the disease.

The study, led by Drs. Helen Tremlett, Afsaneh Shirani, Joel Oger and others, shows no strong evidence that a group of drugs, beta interferons (?-IFNs), prescribed to treat MS had a measurable impact on the long-term disability progression of the disease.

The team examined the linked health records of 2656 BC patients between 1985 - 2008 in a retrospective cohort study, which means data from already collected sources were linked together in an anonymized form and studied. Data sources included the BC Ministry of Health, PharmaNet and the BC Multiple Sclerosis (BCMS) database, facilitated by Population Data BC.

The study population included patients with MS who were treated with beta interferons (?-IFNs), the most widely used treatment for relapsing?remitting MS, as well as untreated MS patients. The research team discovered that administration of ?-IFN was not associated with a significant change in the progression of disability.

These findings will be of interest to MS patients with this form of the disease, but researchers are quick to point out that this is just one measure of these disease modifying drugs and there is still potentially significant benefit to patients.

"What this study provides is additional information to patients and clinicians about the longer term effect of this class of drugs," says corresponding author, Dr. Helen Tremlett (PhD), who also holds the Canada Research Chair in Neuroepidemiology and Multiple Sclerosis at UBC. "We know that this class of drugs is very helpful in reducing relapses, which can be important to patients. We do not recommend that patients stop taking these medications, but these findings provide evidence, allowing more realistic expectations as to the anticipated benefits associated with drug treatment from the disability perspective."

"It is still possible that some patients gain long-term benefit from ?-IFNs. We are currently working toward identifying who those potential treatment responders might be," says Dr Afsaneh Shirani, who is the first author of the paper and a post-doctoral research fellow in the UBC Faculty of Medicine and Brain Research Centre at UBC and VCH Research Institute. "Our study also encourages the investigation of novel treatments for MS," she adds.

"In addition, this study suggests that linked data from health administrative databases have enormous potential for research applications, despite all the challenges of record linkage" says Dr Shirani.

Relapsing-remitting MS is characterized by relapses or "flare-ups" during which time new symptoms can appear or old ones can resurface or worsen. The relapses are followed by periods of remission during which time the person can fully or partially recover. Relapsing-remitting MS is the most common form of MS affecting around 85% of MS patients in Canada.

"In clinical trial situations, it has been quite evident for years that patients receiving ?-IFN treatment have reduced frequency of relapses as well as reduced frequency of new lesions seen on MRI," says Dr. Joel Oger, who is also a neurologist with the UBC Hospital MS Clinic. "This study following a large number of patients for a long time in "real life situation" does not show an association of the ?-IFNs with long term disability and tends to confirm a more modern way of understanding MS: relapses may not be responsible for long term disability in all patients and another mechanism might be at work as well."

The research team is preparing for future studies further examining this and other classes of disease modifying drugs. The hope is that the research will ultimately lead to an individualized approach to the treatment of MS.

###

University of British Columbia: http://www.ubc.ca

Thanks to University of British Columbia for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/121813/Widely_prescribed_MS_treatment_may_not_slow_progression_of_disease

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Wednesday, July 18, 2012

SkyWest pilot takes jarring ride in stolen plane

This undated image provided by the Colorado Springs Police Department on Tuesday, July 17, 2012 shows Brian Joseph Hedglin. The SkyWest Airlines employee wanted in a Colorado murder attempted to steal a passenger plane from a small southern Utah airport then shot himself in the head after crashing the aircraft in a nearby parking lot, officials said Tuesday. Hedglin was wanted in connection with the death of Christina Cornejo, 39, in Colorado Springs. Her body was found Friday by police doing a welfare check at the request of her family. Her death has been ruled a homicide. (AP Photo/Colorado Springs Police Department)

Colorado Army National Guard 2nd Lt. Christina Cornejo, ex-girlfriend of Brian Heglin, is seen in an undated photo provided by the Colorado National Guard. Heglin, a SkyWest Airlines pilot suspected of killing Cornejo, stole an empty 50-passenger jet Tuesday, July 17, 2012 from a small Utah airport, crashed it as he drove near a terminal, then was found dead with a self-inflicted gunshot wound, officials said. Police found the body of Cornejo, 39, on July 13 in Colorado Springs, Colo. Authorities say she had been stabbed multiple times. (AP Photo/Colorado National Guard )

A SkyWest regional jet sits on the tarmac on the opposite end of the St. George Municipal Airport Tuesday, July 17, 2012. A SkyWest Airlines employee wanted in a murder case attempted to steal a passenger plane, then shot himself in the head after crashing the aircraft in a nearby parking lot, officials said Tuesday. Brian Hedglin, 40, scaled a razor wire fence at the St. George Municipal Airport early Tuesday, then boarded the 50-passenger SkyWest jet while the airport was closed, St. George city spokesman Marc Mortenson said. (AP Photo/The Spectrum, Jud Burkett) NO SALES

A front-end loader, dump truck and a street sweeper are used to clean up the parking lot at the St. George Airport Tuesday, July 17, 2012. A SkyWest Airlines employee wanted in a murder case attempted to steal a passenger plane, then shot himself in the head after crashing the aircraft in a nearby parking lot, officials said Tuesday. Brian Hedglin, 40, scaled a razor wire fence at the St. George Municipal Airport early Tuesday, then boarded the 50-passenger SkyWest jet while the airport was closed, St. George city spokesman Marc Mortenson said. (AP Photo/The Spectrum, Jud Burkett) NO SALES

St. George police block the entrance to the St. George Municipal Airport Tuesday, July 17, 2012. A SkyWest Airlines employee wanted in a murder case attempted to steal a passenger plane, then shot himself in the head after crashing the aircraft in a nearby parking lot, officials said Tuesday. Brian Hedglin, 40, scaled a razor wire fence at the St. George Municipal Airport early Tuesday, then boarded the 50-passenger SkyWest jet while the airport was closed, St. George city spokesman Marc Mortenson said. (AP Photo/The Spectrum, Samantha Clemens) NO SALES

SALT LAKE CITY (AP) ? A SkyWest Airlines pilot and murder suspect who stole an empty 50-passenger jet and crashed it as he drove it at a small Utah airport was found dead with a gunshot wound to his head about halfway down the aircraft aisle, police said Wednesday.

Brian Hedglin was wanted in the murder of his girlfriend in Colorado when he used a rug to scale the razor wire-topped fence at the St. George Municipal Airport early Tuesday. The plane crashed in an airport parking lot before it got off the ground.

Authorities were trying Wednesday to determine just how Hedglin gained access to the plane while the airport was closed, among other details.

St. George police Capt. James Van Fleet said investigators were still awaiting toxicology reports to determine whether drugs or alcohol were a factor. He said they were also awaiting data from the cockpit recorder.

"Right now, we just don't know when he was shot," Van Fleet said. "Did he shoot himself at the beginning and the plane went on a ride on its own? We don't know."

The short ride was jarring enough to collapse the plane's front landing gear as it careened over landscaping, crossed a road and hit a curb before crashing into cars in the parking lot, he said.

"He might have been standing in the cockpit and was thrown back," Van Fleet said.

Meanwhile, SkyWest officials said the company deactivated Hedglin's access cards and put him on administrative leave after Colorado authorities named him a murder suspect, but declined to explain how he was able to steal one of their planes.

Van Fleet said he didn't know if the plane was locked, and SkyWest declined to discuss it.

Van Fleet also said that once his officers had finished processing evidence on the plane, it was released to SkyWest, which painted over its logo and moved the aircraft back onto secure airport property.

SkyWest spokeswoman Marissa Snow said the jet was scheduled for a flight later Tuesday morning, but noted it was empty and sitting on the tarmac when Hedglin stole it.

The CRJ200 aircraft is made by Bombardier and is capable of flying up to 534 mph with a range of 1,700 miles. Normally it has a two-person flight crew and one flight attendant.

Hedglin had been a pilot for the airline since 2005, and has flown these specific planes numerous times, Snow said.

Snow declined to say whether the plane was secured at the time of the incident, noting only that "there are numerous federally mandated procedures for securing an aircraft."

"This access was unauthorized," she said, declining to provide specific details about how Hedglin was able to board the plane. She also declined to say whether the plane was fueled up, noting it was all part of an ongoing investigation by local authorities in Utah, federal agencies and the airline.

Marianella de la Barrera, a Toronto-based spokeswoman for Bombardier, said security features vary airline to airline and sometimes even are different within an airline's fleet.

Even though planes can be equipped with or without locking mechanisms, she said training and experience would be needed to operate one.

"An average person wouldn't be able to walk up and start one up," she said.

The incident has raised overall concerns that the nation's airports may not be as safe as they should be.

The Transportation Security Administration doesn't require airports to maintain full-time surveillance of their perimeter fences, leaving airport security largely in the hands of individual facilities. St. George airport officials have said the small facility about 120 miles northeast of Las Vegas meets all federal security guidelines.

Van Fleet said just one officer provides security for the airport as it is closed through the night until 6 a.m. the next morning when TSA officials and others return. He said his agency would be discussing whether additional security measures need to be added but noted "this was a very determined person."

TSA spokesman Dave Castelveter said the agency was involved in the investigation, but declined to discuss specific security protocols, including how a plane is supposed to be secured when it is out of service, emphasizing that each airport has different security needs.

"Aviation security is not a one size fits all process," Castelveter said.

Republican U.S. Rep. Mike Rogers of Alabama, chairman of the Subcommittee on Transportation Security, said the Utah incident "shows major security weaknesses at our airports that need to be addressed."

"We have been pushing TSA to do a much better job overall of working with its partners, including airport authorities, to improve security," Rogers said in a statement Wednesday. "American taxpayers deserve better and have a right to be outraged at this."

One aviation security expert said it might be time to revisit protocols aimed at securing airport perimeters.

"Maybe we need to implement some more levels of perimeter security because any type of security incident like this is a lesson to both the good guys and the bad guys. They read the papers just as much as we do," said Jeff Price, an aviation professor at the Metropolitan State University of Denver and former assistant security director at Denver International Airport.

Hedglin was wanted in the death of his of his girlfriend and fellow Colorado National Guard member, Christina Cornejo, in Colorado Springs, Colo. Her body was found July 13. Authorities said she had been stabbed multiple times. Hedglin was the key suspect but had not been charged.

The Gazette of Colorado Springs, citing court records, reported Hedglin dated Cornejo for four years and was arrested in March after he was accused of harassing her.

The records show that a restraining order was issued against Hedglin, and he was set for trial in August. He was released on $10,000 bond.

Attorney Steven Rodemer, who represented Hedglin in that case, said he was facing misdemeanor charges of criminal mischief, theft and harassment.

Hedglin was a part-time soldier who worked as a cook in the Colorado National Guard.

Cornejo was a full-time soldier who served in the Colorado Army National Guard's 100th Missile Defense Brigade in Colorado Springs. She enlisted in June 2006, became a second lieutenant last year and was named a distinguished honor graduate in two training programs. She had recently begun training as a current operations officer.

___

Associated Press writers Holbrook Mohr in Jackson, Miss., and Colleen Slevin and Dan Elliott in Denver contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-07-18-Utah-Airport%20Investigation/id-108349a992984102b54243a5a93e6229

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Using Social Media With Your Business In 2012 ? What You Need ...

People that operate businesses online have been upset, and confused, by the many Google updates that have transpired. Facebook and other social media sites can announce changes at any time, as well. When it comes to these uncertainties, it becomes problematic for those that use social media and other online resources. It is not necessary to worry about any of this. It is not that big of a deal on the scope of everything. The trick is to update regularly, making sure your social media marketing is at the top of its game. The Internet is going to fluctuate, and you need to be malleable in regard to these changes when they happen. We understand very well that Guru Product Blueprints eben pagan is nothing new within the world of internet marketing and business. There is never anything wrong with testing out something you have just read about, and very often you will discover that you have been overlooking something potentially profitable.

Perhaps only one thing you just learned could be used in your marketing, and if that is the case then you should embrace it. What did you think about this article and the methods discussed? Can they be used in your online business in any form whatsoever? Will you take action to find out? Internet marketing can be frustrating, to be sure, but you have to give your self time to learn a little bit and then it is action time. The overall process is really pretty easy; you find something that looks like it could be good, learn about it and take action on it. This is what forward-thinking business is all about, and that is the only way you can grow and expand.

You just start using the relational attribute that identifies you as the source author for your content. More than likely, you understand why this has to happen, and why it is so important for the success of your business. One of the best ways to do this is to use the tag rel=?author? ? this carries a lot of weight in regard to the social networks. When you use this particular tag, Google looks at this with much more seriousness. Also, this will help your content rank a little better with all other optimization factors considered. This really is necessary for protecting your content in case it is stolen by someone online. If that happens, your own content used by someone else could possibly outrank yours. Many different forms of content exist, not just articles or text that is on your site. You need to use all the various forms and mediums for content as possible. You can improve your overall site by adding things like videos for people to watch or podcasts for them to download. You want to always focus on the basic mechanics of content when thinking of improving your site. But don?t forget that you cannot have low quality content in your videos or other content. Many people do not use this strategy and tend to hurt their business. People will spend more time on your website if you have high quality content. Your bounce rates will also go down.

When it comes to news and the latest events, it is actually in your best interest to use Twitter as much as you can. It just takes a little time, but you can get it done. What you want to do is tweet every time something relevant to your niche or market occurs. Of course what you need to do is tweet about it as it?s happening. We would like to suggest, for an example, that you are in the automotive industry right now. As soon as the Indy 500 begins, you need to tweet about it immediately. You will get more attention and exposure in social media by doing this. In regard to social media, you want to ignore following herd mentality at all times. People that follow this herd mentality will try virtually anything, as long as it is recommended by someone else. Only do things that are beneficial for your business when you make choices. Every decision that you make must be fully processed before you make it.

Source: http://www.nwactc.net/using-social-media-with-your-business-in-2012-what-you-need-to-do/

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75% of World Has Access to Mobile Phones [STUDY]

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Source: http://news.yahoo.com/75-world-access-mobile-phones-study-024118305.html

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Tuesday, July 17, 2012

Soup Skills of Vegetarians | E Publishing

If anything could be considered the heart of great vegetarian cooking it would be the soup. Because soup gives the cook so much freedom to combine various vegetables and herbs, the variety of tastes and consistencies is virtually endless. And because soups capture almost all of the nutrients of the cooking process in the soups stock, it is a dish that meets the highest of nutritional standards will being delicious, hearty and satisfying at the same time.

Another great thing about basing your vegetarian diet plan on soups and stews is that it fits so well with a busy modern lifestyle. Just because you are a vegetarian, you still are busy with work, family and social responsibilities. But with a big crock pot, you can put together a soup for the family that is just as good as if you had labored over it for hours. And when everyone has had their fill of soup, there is no waste because every drop of the excess can be refrigerated for another meal later or frozen be on hand down the road. All of these aspects of soups fill perfectly with the vegetarian way of life.

Creativity should become the guiding principle of your soup planning particularly if you are going to make soups every week for your vegetarian family. Naturally you will have your favorite recopies that everybody will clamor for each week. But every so often, start with a basic soup stock and then get creative from there. You can use as a foundation for y our soup the basics of onions, garlic and the base vegetables such as carrots or celery. But many vegetables will serve well as "surprise guests" in your soup of the week that will not show up every week. Such vegetables as potatoes, cabbage, peppers, cucumbers, watermelon, tomatoes and many more can add tremendous variety to your soup tastes and keep the soup concept constantly new and fresh as a staple of your vegetarian family meal planning.

One cooking skill you should invest some time in to become a top notch vegetarian soup cook is to know your spices. A soup can get pretty bland even with the best of ingredients but the wise and clever use of spices can make a soup come alive with flavor. Each soup ingredient interacts with spices differently. And you can change the very nature of a soup with nothing more than the addition of a few spices. With the addition of cumin and chili powder, a routine tomato soup becomes vegetarian chili. With the addition of Mexican spices, a run of the mill bean soup becomes vegetarian taco soup that can be as spicy as you want it to be. So learn to experiment with spices and get to know what kind of personality different spices like oregano, thyme, rosemary, lemon extract, cilantro and parsley can add to your soup.

Soups are also a wonderful way to blend in lots of different ingredients that your family might not otherwise eat. And since a big priority in vegetarian meal planning is to assure that your family gets the proper nutrition from each meal, you can add beans, rice, tofu and other staples from the vegetarian pantry to expand the nutritional value of your soup so it not only is delicious, it is filling and very healthy as well.

It is possible that at times your family may grow tired of soup after soup. So you might want to experiment with thickening the soup so that by the end of the preparation process, you have a stew that is just as good as soup but has much less liquid broth to present to your hungry vegetarians. Many cooks use cornstarch or flour to turn the broth into more of a paste before serving. Another clever device is to use instant potatoes that are sold in packages of flakes. By sprinkling a package into your soup, the flakes will soak up the soup and add that rich potato flavor to your stew.

Have fun with your soup creations and always be on the lookout for new and interesting soup recipes. The vegetarian web sites and blogs are a constant source of new innovations on the standard soup idea. But by being creative and vigilant in keeping your soups always new and fun, you can use the basic concept as the cornerstone of your vegetarian cooking for many years.

Source: http://e-publishing.org.uk/food-and-drink/vegetarian/soup-skills-of-vegetarians/

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Personal Finance - Helping yourself: Control your Finances with Top ...

At present there are numerous people who are unable to control their expenses and feel that they can never recover from their financial mayhem. But nothing is impossible; if you feel that attaining financial stability is out of your reach, here are some steps that can be taken now to put you in a better financial position in the future.

Tip 1: Spend within your Means

The initial step you need to take is to know how much you spend monthly and how much you are earning; spend only within your earnings never exceed it. The best way to implement is to stay away from your credit cards; when you are in financial difficulties, credit cards dig a deeper financial hole for you. If there are some emergencies arising and you are in need of instant cash you can opt for a payday loan, it will provide you with the cash instantly and you can pay it back with your next paycheck.

Tip 2: Organise your Finances

If you neglect paying your bills on time and ignore your credit card payments thinking that you can do that later on, it would ultimately lead you in late payment fees and penalties. This could also lead you in tarnished credit reports and a lower credit score. To avoid such situations the first thing you need to do is to be financially organised. Prepare a cash-flow calendar for everyone in the home who earns money. Then write down which bills are to be paid on what dates and by whom. This will help to get in a good financial position and become more financially stable.

Tip 3: Track your Expenses

It is very important for you to know where your earnings are being spent. Keep a proper track of all your spending?s for a month this will give you a detailed plan who is spending how much and where. Then according to your spending?s in the house you can prepare a monthly budget plan covering all the necessities and save up some money for the future requirements.

Tip 4: Improve your Credit

If your credit reports are becoming weak because of your recent spending, then work on improving it. Start to prepare a plan for repayments of your debts; initially begin to pay with a smaller amount and then increase it gradually. Your recent payments will create a stronger impact on your credit score and ultimately improve it.

By following each of the above mentioned tips you pave your way to a stronger financial ground.

My name is Michelle. I am a tech writer from UK. I am into Finance.?

Source: http://personalfinance4all.blogspot.com/2012/07/control-your-finances-with-top.html

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